生命的遗传信息储存在核酸的碱基序列上，随着遗传学的发展，人们发现，DNA、组蛋白、染色体水平的修饰也会造成基因表达模式的变化，并且这种改变是可以遗传的，这种现象被称之为表观遗传。
表观遗传学的研究从上个世纪90年代才受到重视。2010年，时代周刊撰文介绍这一新兴学科，从此让世人意识到我们的DNA并不绝对地决定了我们的命运。作为一种重要的调控机制，表观遗传调控在各种生命过程中的作用已经逐步得到人们的认识。经过近20年特别是近年来的研究和发展，表观遗传学研究取得了长足的进展：新的表观遗传修饰方式在不断地被发现；以第二代测序为代表的技术革命使我们能够以前所未有的高精度高通量对各种表观遗传标记进行分析；在医学领域，表观遗传的异常已被认识到在几乎各种疾病包括肿瘤、心血管、代谢、免疫、炎症、神经及精神疾病的发病、转归中起重要作用；环境及生活方式等外界因素通过表观遗传机制对健康产生重要的影响；众多表观遗传修饰有可能或已经成为疾病的诊断标志物；以表观遗传修饰作为靶点的药物已经进入临床使用。
为了提高医学和临床研究工作者对表观遗传学重要性的认识，推动表观遗传学在医学领域的基础和转化研究，我们特组织了本次会议。本会将邀请国内外在表观遗传领域，特别是在表观遗传的转化研究方面有杰出贡献的专家和学者向我们介绍本领域的最新动态和进展，并与参会者一起探讨临床表观遗传学研究的新思路、新方法和新方向。我们相信此次研讨会会激励产生新的想法，促成更深入的合作，促进表观遗传学研究在疾病诊断、治疗和预防中的转化和应用。
Welcome to the 2016 Congress of Medical Epigenetics ? Beijing, China!
Epigenetic marks have been known since 1970 but their importance has not been realized until 1990s. As introduced in a Times cover story in 2010, epigenetics explains why our DNA is not our destiny.
The term of epigenetics refers to stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence. Some of the well-known epigenetic events include covalent modification of DNA, histones, non-histone proteins (e.g., chaperones) as well as the interactions between non-coding RNAs and chromatin. It has become increasingly clear that epigenetics plays important roles in various cellular processes such as stem cells, differentiation, development and in disease as well. In the past two decades, we have witnessed amazing progress in the field of epigenetics: New epigenetic modifications are being constantly discovered; Rapid technological advances such as next-generation sequencing allow for mapping and analyzing epigenetic marks at an unprecedented resolution and accuracy; epigenetic aberrations have been recognized to be tightly associated with almost all major diseases, including cancer, cardiovascular and metabolic disorders, autoimmune and neurological diseases; In particular, the impact of inheritable epigenetic changes caused by environmental factors and life style on health is being increasingly unveiled; The value of epigenetic biomarkers in disease diagnosis and prognosis has been firmed established; A number of drugs that target epigenetic pathways have advanced into clinic.
This symposium will cover some of the most recent advances and cutting edge research in the field of epigenetics, especially translational epigenetics. We believe that this meeting will inspire new ideas, foster collaborations and boost the translation of epigenetic researches into diagnosis, therapies and preventions.
会议时间：2016年3月18-20日
大会主席：曹雪涛
大会副主席：邓大君 刘喆 肖新华
大会执行主席：李龙承
大会执行副主席：彭小忠
大会秘书长： 吴旭东 徐国纲
大会学术和组织委员会 （按姓氏排名）：曹雪涛 邓大君 郭明洲 何爱彬 李恩 李龙承 鲁先平 刘喆 彭小忠 汤富酬 吴国瑞 王利 吴旭东 徐顺清 肖新华 于力
会议地点：北京.协和学术会堂（东城区王府井大街帅府园胡同内协和医院西门对面）
交通指南：地铁1号线王府井站A口出，沿王府井大街步行440米，右转进入帅府园胡同，直行120米即到；地铁5号线东单站，A口出，步行约900米即到。
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3月18日星期五 Day 0 - Friday, March 18th |
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14:00-22:00 |
会议注册 Registration |
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3月19日星期六 Day 1 - Saturday, March 19th |
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时间 Time |
讲题 Title |
讲者 Speaker |
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08:30-08:45 |
开幕式 Opening ceremony |
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08:45-09:35 |
免疫与炎症的表观调控 Epigenetic regulation of immunity and inflammation |
曹雪涛 Xuetao Cao |
大会特邀报告 |
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09:35-12:05 |
肿瘤表观遗传与生物标志物 |
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09:35-10:05 |
肿瘤诊断及分型的表观遗传标志物 Epigenetic biomarkers for cancer diagnosis and subtype classification |
Tim Huang |
大会主题报告 |
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10:05-10:25 |
癌转移中的淋巴细胞拟态 Lymphocyte mimicry in epithelial cancer metastasis |
刘喆 Zhe Liu |
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10:25-10:45 |
茶歇及壁报展示 |
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10:45-11:05 |
缺氧介导的上皮间充质转化中翻译后修饰及表观遗传调控 Post-translational and Epigenetic Regulations of Hypoxia-mediated Epithelial-mesenchymal Transition |
吴国瑞 Guorui Wu |
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11:05-11:25 |
核内miRNA介导的转录基因激活 Transcriptional gene activation by nuclear activating miRNA |
于文强 Wenqiang Yu |
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11:25-11:45 |
p16基因DNA甲基化直接驱动肿瘤发生发展 DNA methylation of p16 gene promotes carcinogenesis and cancer development |
邓大君 Dajun Deng |
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11:45-12:05 |
肾癌预后监测的新型表观标记物: 5-羟甲基胞嘧啶(5hmC) Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer |
慈维敏 Weimin Ci |
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12:05-13:30 |
午餐及壁报展示 |
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13:30-15:00 |
表观遗传与衰老、发育及生殖健康 |
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13:30-14:00 |
人类早期胚胎基因表达的表观遗传学调控 Epigenetic regulations of gene expression in human early embryos |
汤富酬Fuchou Tang |
大会主题报告Keynote lecture |
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14:00-14:20 |
神经发育及神经系统疾病中的DNA甲基化 DNA methylation in neural development and neurological disorders |
范国平 Guoping Fan |
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14:20-14:40 |
发育及肿瘤中H2AK119的单泛素化失调 Dysregulated H2AK119 monoubiquitylation in development and cancer |
吴旭东 Xudong Wu |
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14:40-15:00 |
神经发育性疾病中的表观遗传学网络 Epigenetic networks in neurodevelopmental disorders |
胡昊 Hao Hu |
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15:00-15:20 |
茶歇及壁报展示 |
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15:20-17:00 |
表观遗传与心血管、神经及精神疾病 |
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15:20-15:50 |
TBD |
彭小忠Xiaozhong Peng |
大会主题报告 |
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15:50-16:10 |
ncRNA in human gliomas 非编码RNA在胶质瘤中的作用 |
康春生 Chunsheng Kang |
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16:10-16:30 |
Polycomb亚基 EED调控心脏成熟不依赖于PRC2 Polycomb EED orchestration of heart maturation does not depend on PRC2 |
何爱彬 Aibin He |
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16:30-16:50 |
组蛋白去乙酰化酶SIRT1在年血管老化及年龄相关疾病中的保护作用 Protective roles of histone deacetylase SIRT1 in vascular aging and age-related diseases |
陈厚早 Houzao Chen |
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3月20日星期日 |
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时间 Time |
讲题 Title |
讲者 Speaker |
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08:30-10:50 |
表观遗传与环境、营养、内分泌及代谢性疾病 |
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08:30-09:00 |
环境表观遗传学：健康及疾病的决定因素 Environmental Epigenetics: A Determinant of Health and Disease Outcomes |
Shuk-Mei Ho |
大会主题报告Keynote lecture |
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09:00-09:20 |
生命早期营养干预的理论与实验基础 Theoretical and experimental basis of nutritional intervention in early life |
张霆 Ting Zhang |
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09:20-9:40 |
环境污染的表观遗传效应与成年疾病的发育起源 Epigenetic impacts of environmental pollution and developmental origins of adult disease |
徐顺清 Shunqing Xu |
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9:40-10:00 |
糖尿病发生发展的表观遗传机制 Epigenetic mechanisms of diabetes |
肖新华 Xinhua Xiao |
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10:00-10:20 |
靶向染色质重塑复合物调控干细胞分化决策及肿瘤转移 Targeting chromatin remodeling complex to regulate pluripotent stem cell fate decisions and cancer progression |
王利 Li Wang |
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10:20-10:40 |
茶歇 |
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10:40-12:00 |
表观遗传与血液、免疫／炎症性疾病 |
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10:40-11:10 |
表观遗传修饰在正常人及老年人造血中的作用 The role of epigenetic modifiers in normal and aged hematopoiesis |
Gerald de Haan |
大会主题报告Keynote lecture |
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11:10-11:30 |
固有免疫中的表观遗传：机制及应用 Epigenetics in innate immunity: mechanisms and implications |
王玺 Xi Wang |
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11:30-11:50 |
基于定量蛋白组学的精准生物标记物研究 An integrated quantitative proteomics approach for biomarker discovery in precision medicine |
程仲毅 Zhongyi Cheng |
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12:00-13:30 |
午餐及壁报展示 |
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13:30-15:50 |
表观遗传治疗及精准医学 |
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13:30-14:00 |
TBD |
李恩En Li |
大会主题报告 |
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14:00-14:20 |
以表观基因组为基础的肿瘤精准治疗 Precision medicine based on Epigenomics |
郭明洲 Mingzhou Guo |
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14:20-14:40 |
骨髓增生异常综合征/急性髓系白血病去甲基化治疗基础及临床研究 Fundamental and clinical research of demethylation in myelodysplastic syndrome/acute myeloid leukemia |
于力 Li Yu |
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14:40-15:00 |
茶歇 |
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15:00-15:20 |
组蛋白修饰与肿瘤细胞DNA损伤修复 Histone modification and repair of DNA damage of tumor cells |
朱卫国 Weiguo Zhu |
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15:20-15:40 |
选择性组蛋白去乙酰化酶抑制剂西达本胺在复发难治性淋巴瘤中的精准治疗前景 Therapeutic potential of selective HDAC inhibitor chidamide and precision treatment for relapse and recurrent lymphomas patients |
鲁先平 Xianping Lu |
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结束 |
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